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Updated: Aug 8, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
The nuclear factor kappa B and Spl binding sites do not appear to be involved in virus suppression by CD8 T
C P Locher1, S A Witt, J A Levy
1Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143-1270, USA.
Abstract:
CD8 T lymphocytes suppress primate lentivirus replication in a non-cytotoxic manner. This antiviral activity, mediated by a CD8 cell antiviral factor (CAF), involves an arrest in viral transcription. Present studies indicate that the CD8 T cell non-cytotoxic antiviral activity and CAF inhibit the replication of an SIV mutant virus lacking the nuclear factor kappa B (NF-kappaB) and Spl binding domains. The results strongly suggest that the NF-B and Spl binding sites are not involved in virus suppression by CD8 T lymphocytes.
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