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Chronomics.

F E Halberg1, G Cornélissen, K Otsuka

  • 1Halberg Chronobiology Center University of Minnesota, Minneapolis, USA.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 5, 2002
PubMed
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Biological rhythms extend beyond daily and yearly cycles, including non-photic environmental influences. Chronome mapping helps optimize lifestyle, chronoprevention, and chronotherapy for health and understanding life's evolution.

Area of Science:

  • Chronobiology and chronomics
  • Investigates biological rhythms and their environmental influences

Background:

  • Established daily and yearly biological rhythms are influenced by light (photic).
  • Evidence suggests additional non-photic, heliogeophysical rhythms (e.g., 7-day, 27-day, yearly cycles) affect individuals and populations.
  • These rhythms complement the established biological day and year.

Purpose of the Study:

  • To quantify rhythms, chaos, and trends within biological time series using chronome mapping.
  • To assess chronobiological methodology for comparing endpoints before and after lifestyle changes, interventions, or treatments.
  • To explore the potential of chronome mapping for individualized lifestyle optimization, chronoprevention, and chronotherapy.

Main Methods:

  • Analysis of dense and long time series (biological or other) to quantify rhythms, chaos, and trends.

Related Experiment Videos

  • Chronobiological methodology to assess uncertainties in endpoint comparisons.
  • Evaluation of interventions including lifestyle changes (diet, salting), preventive non-drug interventions, and drug treatments.

    • Main Results:

    • Identification and quantification of various biological rhythms, including photic and non-photic influences.
    • Demonstration of chronome mapping's ability to analyze complex time series.
    • Assessment of how lifestyle, interventions, and treatments affect chronomic elements.

    Conclusions:

    • Chronome mapping provides a framework for understanding and quantifying biological structures (chronomes).
    • Chronobiological methods can assess interventions and lifestyle impacts on health.
    • Chronome mapping holds potential for personalized health optimization, chronoprevention, chronotherapy, and advancing chronoastrobiology.