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Updated: Jul 29, 2026
05:46
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
Published on: January 24, 2013
Circadian and infradian rhythms in mood
G Mitsutake1, K Otsuka, G Cornélissen
1University of Manitoba, Winnipeg, Canada.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 5, 2002
Summary
This study found that greater daily swings in negative emotions correlate with higher blood pressure. Positive and negative emotions did not show a significant relationship in this longitudinal mood and health data analysis.
Area of Science:
- Chronobiology
- Cardiovascular Physiology
- Affective Science
Background:
- Longitudinal mood variations and their physiological correlates are not well understood.
- Previous studies often used cross-sectional designs, limiting insights into dynamic relationships.
Purpose of the Study:
- To longitudinally assess variations in positive and negative affect.
- To compare findings with previous population studies.
- To investigate associations between mood, cardiovascular, hormonal, and geophysical variables.
Main Methods:
- A single healthy male participant completed the Positive and Negative Affect Schedule (PANAS) five times daily for 86 days.
- Ambulatory monitoring of systolic/diastolic blood pressure (SBP/DBP) and heart rate (HR) at 30-minute intervals.
- Electrocardiogram (ECG) monitoring for heart rate variability (HRV) and saliva samples for cortisol and melatonin levels were collected.
- Chronobiologic serial section analysis was used to assess circadian characteristics and correlations between variables.
Main Results:
- Circadian rhythms were observed for all monitored variables (affect, blood pressure, heart rate, HRV, hormones).
- A significant positive association was found between the circadian amplitude of negative affect and the mean (MESOR) of both SBP (r=0.363, P=0.029) and DBP (r=0.389, P=0.019).
- No statistically significant relationship was found between positive and negative affect measures.
Conclusions:
- Increased variability in negative affect is associated with elevated blood pressure.
- Circadian rhythms play a role in the interplay between mood and cardiovascular function.
- Further research is needed to validate observed associations and explore underlying mechanisms.
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