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Is nausea associated with chronic hepatitis C infection?
T R Riley1, V M Chinchilli, M Shoemaker
1Department of Medicine and Health Evaluation Sciences, The Pennsylvania State University-The Hershey Medical Center, 17033, USA.
The American Journal of Gastroenterology
|January 5, 2002
Summary
Hepatitis C virus (HCV) infection significantly increases the risk of nausea, fatigue, and abdominal pain. Nausea is notably more prevalent in HCV patients compared to healthy individuals and those with other liver diseases.
Area of Science:
- Hepatology
- Gastroenterology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) infection is a global health concern.
- Commonly associated symptoms include fatigue and right upper quadrant pain.
- Nausea is a potentially underrecognized symptom in HCV patients.
Purpose of the Study:
- To determine the frequency of nausea in patients with HCV infection.
- To compare nausea prevalence in HCV patients against control groups.
- To investigate the association of nausea with other symptoms and HCV diagnosis.
Main Methods:
- Cross-sectional study design with consecutive outpatients.
- Utilized dyspepsia and Nausea Profile questionnaires.
- Employed univariate and multivariate statistical analyses.
Main Results:
- HCV patients exhibited a higher prevalence of nausea (43%) compared to normal controls (29.7%) and liver disease controls (18.9%).
- HCV patients reported increased fatigue and abdominal pain.
- Nausea Profile scores were significantly higher in HCV patients, independently associated with HCV diagnosis, fatigue, and abdominal pain.
Conclusions:
- HCV infection is linked to a substantially increased risk of nausea.
- The strong correlation between abdominal pain and nausea suggests a potential etiological pathway.
- Further research is warranted to elucidate the specific causes of nausea in HCV patients.
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