Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue viral load variability in chronic hepatitis C.

L Fanning1, J Loane, E Kenny-Walsh

  • 1Department of Medicine, Cork University Hospital, National University of Ireland.

The American Journal of Gastroenterology
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-site validation of an AI-based biomarker test for determining ER, PR, and HER2 status from H&E-stained breast cancer slides.

ESMO real world data and digital oncology·2026
Same author

Correction: Microbiota is essential for social development in the mouse.

Molecular psychiatry·2026
Same author

Visual access to an outdoor range early in life, but not environmental complexity, increases meat chicken ranging behavior.

Poultry science·2023
Same author

Safety of <i>Bifidobacterium breve</i>, Bif195, employing a human exercise-induced intestinal permeability model: a randomised, double-blinded, placebo-controlled, parallel group trial.

Beneficial microbes·2022
Same author

Modulation, microbiota and inflammation in the adult CF gut: A prospective study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2022
Same author

Metagenomic assembled plasmids of the human microbiome vary across disease cohorts.

Scientific reports·2022

Viral load in liver biopsies shows consistent results between lobes, unlike histology. This suggests hepatic viral load assessment is more reliable than histological analysis in chronic hepatitis C patients.

Area of Science:

  • Hepatology
  • Virology
  • Medical Diagnostics

Background:

  • Liver biopsy is the standard for assessing chronic hepatitis C (HCV) disease activity.
  • Sampling variability in liver biopsies can limit histological assessment accuracy.
  • Uncertainty exists regarding whether viral load assessment is subject to similar sampling variability.

Purpose of the Study:

  • To compare viral load and histological assessment between right and left liver lobe biopsy specimens in HCV-infected patients.
  • To determine if sampling variability affects hepatic viral load measurements similarly to histology.

Main Methods:

  • Bilateral liver biopsies were performed on 16 HCV RNA-positive patients.
  • HCV genotype, histology, and hepatic viral load were assessed blindly.

Related Experiment Videos

  • Patients had no other liver diseases or competing risk factors and were treatment-naïve.

    • Main Results:

    • Hepatitis C virus (HCV) detection was concordant between lobes and serum.
    • Hepatic viral load demonstrated high correlation between right and left lobes (r=0.79, p=0.0003).
    • Histological indices for inflammation (r=0.60, p=0.038) and fibrosis/cirrhosis (r=0.50, p=0.098) showed poor correlation between lobes.

    Conclusions:

    • Hepatic viral load assessment in chronic hepatitis C exhibits significantly less sampling variability compared to histological evaluation.
    • Viral load measurements from different liver lobes are more consistent than histological findings.
    • This suggests hepatic viral load is a more reliable marker of disease activity in HCV due to lower sampling heterogeneity.