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Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: the HyperGEN

D K Arnett1, Y Hong, J N Bella

  • 1Division of Epidemiology, University of Minnesota, Minneapolis 55455-1015, USA. arnett@epi.umn.edu

American Journal of Hypertension
|January 5, 2002
PubMed
Summary

Genetic factors significantly influence left ventricular (LV) mass in African American siblings more than in white siblings. Echocardiographic LV mass and relative wall thickness (RWT) genetic underpinnings may differ between ethnic groups.

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Area of Science:

  • Cardiovascular Genetics
  • Clinical Echocardiography
  • Population Health

Background:

  • Left ventricular (LV) mass is influenced by genetic factors, independent of known risk factors.
  • Understanding ethnic variations in genetic control of LV mass is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate familial correlations of LV mass and relative wall thickness (RWT) in African American and white hypertensive siblings.
  • To explore potential ethnic differences in the genetic basis of LV hypertrophy and geometric remodeling.

Main Methods:

  • Recruited 1,664 African American and white hypertensive siblings for the HyperGEN study.
  • Measured LV mass and RWT using echocardiography.
  • Calculated familial correlations adjusted for age, gender, blood pressure, and obesity.

Main Results:

  • LV mass showed stronger sibling correlations in African Americans (0.29-0.44) compared to whites (0.05-0.22).
  • RWT sibling correlations were higher in whites (0.19-0.28) than in African Americans (0.04-0.12).

Conclusions:

  • LV mass is strongly heritable in hypertensive African American siblings, moderately in whites.
  • RWT heritability is greater in whites than in African Americans.
  • Ethnic disparities in genetic influences on LV mass and geometry are suggested.