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Mannitolum infusion on cirrhotic patients with tense ascites treated by paracentesis
1Department of Digestion, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China.
Objective:
To investigate whether albumin can be substituted by mannitolum in cirrhotic patients with tense ascites treated by paracentesis.
Methods:
Sixty-eight patients admitted to this therapeutic procedure were randomly assigned to receive intravenous albumin (36 patients) and mannitolum (32 patients) infusion. In repeated large-volume paracentesis (3-6 L/day), intravenous albumin 20 g or intravenous 20% mannitolum 250 ml were added.
Results:
In 24 and 48 hours after paracentesis the mean value of electrolytes, liver and renal functions and various indicators of systemic circulation either in Group 1 or in Group 2 cases were found without changes (P > 0.05). As compared with that before paracentesis, the diameter of spleen vein was increased significantly (P < 0.05). The complications occurring after paracentesis were similar in both groups.
Conclusions:
It was suggested that paracentesis with intravenous infusion of mannitolum is an effective and safe method in treating cirrhotic patients with tense ascites.