The synergistic enhancement of pathology in intermittently cooled nerve
1Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China. jjpneuro@public3.bta.net.cn
Objective:
To explore how non-freezing cold nerve injury (NFCNI) is affected by fluctuating ambient temperatures.
Methods:
The sciatic nerves of Wistar rats were exposed to either intermittent cooling and rewarming or continuous cooling. The pathology was assessed neurophysiologically and morphologically.
Results:
More severe injury was observed when nerve was intermittently cooled, despite an identical duration and degree of cooling.
Conclusion:
The observed pathology is a result of repeated reperfusion injury to nerves that are cooled intermittently.
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