Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endotoxin: friend or foe?

A H Liu1, A H Redmon

  • 1Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA.

Allergy and Asthma Proceedings
|January 5, 2002
PubMed
Summary

Environmental endotoxin exposure is a double-edged sword, potentially causing respiratory issues like asthma and allergies, but also offering protection against atopy in early childhood by influencing immune development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical observation of enteral nutrition support in pediatric patients after heart transplantation].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2025
Same author

[Midterm and long-term angiographic outcomes and efficacy analysis of the Pipeline Embolization Device in the treatment of intracranial aneurysms].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2024
Same author

[Analysis of pediatric heart transplantation supported by extracorporeal membrane oxygenation].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same author

Examining the effect of ions and proteins on the heat dissipation of iron oxide nanocrystals.

RSC advances·2022
Same author

[Endovascular thrombectomy in patients with intracranial large artery occlusion and atrial fibrillation].

Zhonghua yi xue za zhi·2019
Same author

[Clinical analysis of five cases of autism spectrum disorder complicated with epilepsy with chromosome copy number variation].

Zhonghua yi xue za zhi·2019

Area of Science:

  • Environmental immunology
  • Allergy and asthma research
  • Microbial-host interactions

Background:

  • Endotoxin, initially known for causing septic shock, is increasingly recognized for its environmental impact.
  • Occupational dust exposure to endotoxin is linked to respiratory problems, including airflow obstruction, asthma, and allergies.
  • Emerging research suggests early-life environmental endotoxin exposure may protect against atopy.

Purpose of the Study:

  • To explore the dual role of environmental endotoxin in human health.
  • To understand endotoxin's impact on immune system development and allergic diseases.
  • To investigate the potential atopy-protective effects of early childhood endotoxin exposure.

Main Methods:

  • Review of existing literature on endotoxin's effects in occupational and early-life settings.
  • Analysis of immunological responses, particularly Th1-type immune development.
  • Correlation studies between environmental endotoxin levels and allergic outcomes.

Main Results:

  • Endotoxin acts as a respiratory irritant, exacerbating asthma and allergies in occupational settings.
  • Early-life exposure to environmental endotoxin may promote a protective immune profile, reducing atopy risk.
  • The immune-modulating effects of endotoxin are complex and context-dependent.

Conclusions:

  • Endotoxin exhibits a paradoxical dual nature, contributing to disease and potentially offering protection.
  • Understanding endotoxin's interaction with the immune system is crucial for managing allergic diseases.
  • Further research into bioactive environmental exposures can illuminate immune system guidance in health and disease.

Related Experiment Videos