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Platelet-derived growth factor and basic fibroblast growth factor immunolocalized in proliferative retinal diseases
1Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China.
Objective:
To study the role of platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) in the development of proliferative vitreoretinopathy (PVR).
Methods:
Immunohistochemical localization was performed on frozen sections of the epiretinal or subretinal membranes from 21 PVR patients using! monoclonal antibodies against PDGF and bFGF and the streptavidin peroxidase system.
Results:
PDGF was expressed in 15 of 21 specimens (71.4%), and bFGF was expressed in 14 specimens (66.7%). Different cell density was seen in different types of epiretinal membranes. The cell density of vascular membranes induced by PDR and Eales disease was the highest (> or = 61 cells/field, x 1000); nonvascular membranes induced by PVR or traumatic PVR had moderate cell density (31-60 cells/field); and the macular membrane had the lowest cell density (< or = 30 cells/field).
Conclusion:
The presents of PDGF and bFGF in PVR tissues suggest that PDGF and bFGF may play an important role in the development of PVR.
