Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent development in NMDA receptors.

Y Liu1, J Zhang

  • 1National Institute of Mental Health, 36 Convent Dr. MSC 4033, Building 36, Room 1A31, Bethesda, MD 20892, USA.

Chinese Medical Journal
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

Superantigen reactivity of gamma delta T cell clones isolated from patients with multiple sclerosis and controls.

Cellular immunology·1995
Same author

Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein.

The Journal of pharmacology and experimental therapeutics·1995
Same author

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

The American journal of pathology·1995
Same author

Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.

Molecular and cellular biology·1995
Same author

A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity.

Nature genetics·1995
Same journal

Chronic kidney disease in women: Global trends and metabolic-cardiovascular associations.

Chinese medical journal·2026
Same journal

Uptake and associated factors of breast cancer screening using mammography and ultrasound in China: A multicenter population-based study.

Chinese medical journal·2026
Same journal

Oncogenic DNMT3B as a therapeutic target for cervical cancer.

Chinese medical journal·2026
Same journal

Age of onset by temporal and spatial changes and prognostic value for esophageal cancer.

Chinese medical journal·2026
Same journal

Secular trends in society-, school-, and individual-level factors related to physical activity and their associations with elevated blood pressure among 0.6 million children and adolescents.

Chinese medical journal·2026
Same journal

Role of incretins in Alzheimer's disease and their impact on behavioral aspects.

Chinese medical journal·2026
See all related articles

This review details the structure and function of N-methyl-D-aspartate (NMDA) receptors, highlighting their modulation by various compounds. Understanding these mechanisms is crucial for developing new NMDA receptor-targeting drugs.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • NMDA receptors are critical ion channels involved in synaptic plasticity and neurotransmission.
  • Dysregulation of NMDA receptor function is implicated in various neurological disorders.

Purpose of the Study:

  • To elucidate the structural and functional characteristics of NMDA receptors.
  • To investigate the modulatory effects of endogenous and exogenous compounds on NMDA receptors.
  • To establish a theoretical foundation for novel NMDA receptor-modulating drug development.

Main Methods:

  • Systematic review of 24 selected scientific articles.
  • Expert extraction of meaningful results and conclusions based on scientific criteria.

Related Experiment Videos

Main Results:

  • NMDA receptors comprise at least five subunits (NR1, NR2A-D).
  • Efficient gating requires both glutamate and glycine.
  • Receptor activity is modulated by ions (Mg2+, Na+, K+, Ca2+, Zn2+), polyamines, and pH.
  • NMDA receptors are integral to excitatory synaptic transmission and are implicated in physiological and pathological processes.

Conclusions:

  • NMDA receptors possess a complex subunit structure and gating mechanism.
  • A variety of endogenous and exogenous substances significantly modulate NMDA receptor activity.
  • Further research into NMDA receptor modulation can guide the development of targeted therapeutics.