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[Serum lipoprotein(a) in woman with pregnancy induced hypertension]
1Department of Obstetrics and Gynecology, 2nd Affiliated Hospital, Dalian Medical University, Dalian 116001, China.
Objective:
To examine lipoprotein(a) level in woman with Pregnancy induced hypertension (PIH) to elucidate the effect of it on the pathogenesis of the disease.
Methods:
Serum lipoprotein (a) total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured in 20 normal pregnant woman (control group) and 32 pregnant woman with PIH (PIH group). The PIH group was further divided into the following subgroup: mild, moderate, and severe PIH. We used a transmission turbidimetry method to measure serum lipoprotein(a).
Results:
(1) The serum lipoprotein (a) levels were higher in PIH group than that in control group (228 +/- 187 mg/L vs 106 +/- 93 mg/L). (2) The serum lipoprotein (a) levels were higher in all PIH subgroups than that in control. (3) The serum levels of TC, TG, LDL-C in the PIH group were higher than those in control, while the level of HDL-C in the PIH group was lower than that in control (0.98 +/- 0.16 mmol/L vs 1.09 +/- 0.17 mmol/L).
Conclusions:
This study has demonstrated that lipoprotein (a) levels are elevated in pregnant woman with PIH and associated with severity of the disease. It may involved in the pathogenesis of PIH.
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