[Study on relationship between endometrium laminin expression and irregular uterine bleeding in Norplant users]
1Department of Reproductive Medicine, Capital University of Medical Sciences, Beijing 100054, China.
Objective:
To investigate the relationship between endometrium laminin (LN) expression and irregular uterine bleeding in Norplant users.
Methods:
Eighteen endomerium samples obtained during day 10-14th from Norlant users for 1/2, 1 or > 2 years respectively with irregular bleeding were studied morphologically and immunohistochemically for LN expression. Six normal proliferative endometria and 18 connterpacts with regular bleeding were used as control.
Results:
In Norplant users, endometrial glands decreased in numbers and asynchromized in appearance. The LN expression on basal lamina of glandular epithelium and vascular endothelium was lower in those with irregular bleeding as compared with regular bleeders (P < 0.05).
Conclusion:
The decline of LN expression may related to irregular bleeding in Norplant users.
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