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99mTc-MIBI and 99mTc-MDP scintimammography for detecting breast carcinoma
1Department of Nuclear Medicine, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China.
Objective:
To assess the value of scintimammography with both 99mTc-MIBI and 99mTc-MDP in detecting breast cancer.
Methods:
A total of 35 women with clinical findings of suspicious breast lesions were studied with both 99mTc-MIBI and 99mTc-MDP scintimammography. All patients underwent surgery within one week and the final diagnostic results (histopathological) were obtained.
Results:
Eighteen of 35 abnormalities of breast were pathologically confirmed as breast cancer and 17 as benigN lesions. In this group of patients studied, the sensitivity, specificity and accuracy of 99mTc-MIBI scintimammography were 77.8%, 88.2% and 82.9%, respectively and those of 99mTc-MDP scintimammography were 72.2%, 88.2% and 80.0%, respectively. There was no significant difference between 99mTc-MIBI and 99mTc-MDP scintimammography.
Conclusion:
This study showed the high diagnostic accuracy of both 99mTc-MIBI and 99mTc-MDP scintimammography in detecting breast cancer. Both can be used as non-invasively assess breast cancer invasiveness before surgery.