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[Immunotherapy by B-lymphocytes in patients with unexplained habitual abortion]
Objective:
To investigate the safety and efficacy of immunotherapy in patients with unexplained habitual abortion(UHA) with increased human leukocyte antigen (HLA) mutual antigen.
Methods:
Twenty-four UHA women were immunized by their husband's B-lymphocytes for 3 months.
Results:
Twenty-two of them had increased HLA mutual antigen. The their anti-paternal lymphocytotoxic antitody (APCA) positive rate was 8% before immunization, significantly lower than that of the control group (86%). After immunization, the APCA positive rate increased significantly to 75%, 20 cases achieved pregnancy and 16 deliverd normal newborns.
Conclusion:
Immunotherapy by husband's B-lymphocytes is effective in UHA with increased HLA mutual antigen, and may have less adverse effect.