Related Experiment Video
Updated: Oct 3, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
[Change of plasma cellular fibronectin values in hypertension disorders of pregnancy]
1Department of Obstetrics and Gynecology, Third Affiliated Hospital, Hunan Medical University, Changsha 410013, China.
Objective:
To investigate change of plasma values of cellular fibronectin (cFN) in pregnant women with hypertension diseases.
Methods:
One hundred and twelve pregnant women were assigned into five groups according to definition of hypertension diseases in pregnancy published by the National Working Group on Hypertension. The values of plasma cFN were measured with enzyme-link immunosorbent assay (ELISA). Statistical tests were performed with Variance Analysis (Scheff's post-hoc).
Results:
Plasma cFN values in women of preeclamptic group (12.25 +/- 4.00) mg/L and superimposed preeclamptic group (11.33 +/- 3.74) mg/L were both significantly higher than those of normal group (5.06 +/- 1.33) mg/L (P < 0.01). However, cFN values were not statistically different between women of chronic hypertension or transient hypertension and of normal women (P > 0.05).
Conclusion:
The clinical detection of plasma cFN values appears to be useful in differentiating various hypertension diseases of pregnancy and in selection of relevant treatment regimen.
Related Concept Videos
Fibronectins Connect Cells with ECM
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Hormonal Regulation
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Hypertension II: Pathophysiology
Alterations in Blood Pressure
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
