Related Experiment Videos
[Expression of epidermal growth factor receptor in human preimplantation embroys]
1Department of Obstetrics and Gynecology, Wulumuqi General Hospital, Lanzhou Military Area, Wulumuqi 830000, China.
Objective:
To investigate the expression of epidermal growth factor receptor (EGFR) in human preimplantation embryos and to explore the effect of EGFR on human embryos growth, development and implantation.
Methods:
To detect the localization and expression of EGFR in human preimplantation embryos with indirect immunofluorescence assays(IIF).
Results:
There was EGFR expression in human preimplantation embryos from unfertilized oocyts, 2-cell, 4-cell, 6-8 cell to 10-cell stages embryos. EGFR protein located on the cell membrance surface, and had no obvious variation in intensity of staining from whole stages embryos.
Conclusion:
The expression of EGFR was present in human preimplantation embryos, heparin-binding EGF-like epidermal growth factor (HB-EGF), one of the EGF superfamily members act through the EGFR, EGFR expression may have an important role in human embryos growth, development and implantation.