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[The effect of gancao on glucocorticoid receptors in chronic obstructive pulmonary disease]
1Department of Respiratory Medicine, Second Hospital, Hebei Medical University, Shijiazhuang 050000.
Objective:
To study the effect of gancao and glucocorticoid on glucocorticoid receptors.
Methods:
The number of GCR of peripheral blood leukocytes was determined and FEV1% was assessed in 45 COPD patients and 10 control subjects.
Results:
GCR was significantly lower in COPD patients during acute attack than in control subjects while F and ACTH were significantly higher (P < 0.001). In gancao, glucocorticoid and combination of gancao and glucocorticoid treated groups FEV1% was higher after treatment, especially in the combination group(P < 0.001). Gancao induced up-regulation of GCR while glucocorticoid induced down-regulation of GCR, but combination of gancao and glucocorticoid had no effect on GCR.
Conclusions:
Gancao might reverse the down-regulation of glucocorticoid on GCR, thus enhance and prolong the effects of glucocorticoids.
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