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[Clostridium difficile bacteremia].

A Duthilly1, K Blanckaert, B Thielemans

  • 1Service de microbiologie, CH. Valenciennes.

Presse Medicale (Paris, France : 1983)
|January 5, 2002
PubMed
Summary
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Clostridium difficile can cause rare systemic infections, even outside the digestive tract. This case highlights that bacteremia is a possible, though uncommon, complication in immunocompromised patients.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Critical Care Medicine

Background:

  • Extra-digestive manifestations of Clostridium difficile infection are rare.
  • Clostridium difficile is a common cause of nosocomial diarrhea, often linked to antibiotic use.
  • Systemic infection is an exceptional but documented complication, particularly in intensive care settings.

Observation:

  • A 66-year-old immunocompromised patient with acute myeloblastic leukemia developed Clostridium difficile bacteremia.
  • The bacteremia was associated with an abscess of the anal margin.
  • The patient received metronidazole for treatment.

Findings:

  • Clostridium difficile bacteremia can occur in immunocompromised individuals.
  • Early identification and treatment of Clostridium difficile infection are crucial.

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  • Favorable outcomes are possible with appropriate antimicrobial therapy.

    • Implications:

    • This case underscores the importance of considering Clostridium difficile in systemic infections among immunocompromised patients.
    • It highlights the potential for Clostridium difficile to cause severe, disseminated disease beyond the gastrointestinal tract.
    • Further research into the mechanisms and management of extra-digestive Clostridium difficile infections is warranted.