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[A preliminary study on the markers of pulmonary vascular endothelial cells in patients with ARDS]
1Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037.
Objective:
To explore the changes of the markers of pulmonary vascular endothelial cell (PVEC) in patients with ARDS.
Methods:
The levels of plasma circulating endothelial cell(CEC), granule membrane protein-140(GMP-140), endothelin-1(ET-1) and von Willebrand factor (vWF) were determined respectively in 13cases of ARDS. The vWF on the surface of the PVEC were stained in 5 cases of ARDS.
Results:
Circulating CEC, GMP-140, ET-1 and vWF levels were increased significantly (P < 0.01) but scores of vWF expression on the PVEC became weak (P < 0.01) in ARDS samples. The level of plasma GMP-140 elevated dramatically in 2nd day( > 4 times).
Conclusions:
PVEC are severely impaired during ARDS. GMP-140 released from PVEC might be a satisfactory criteria for early surveillance and for evaluation of prognosis of ARDS in clinical practice.