Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The study on COPD rat model produced by bacterial infection].

H Xu1, M Xiong, Q Huang

  • 1Department of Pathology, Tongji Medical University, Wuhan 430030.

Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases
|January 5, 2002
PubMed
Summary

Bacterial infections with Klebsiella pneumoniae or pneumococcal pneumoniae can cause small airway inflammation and emphysema in rats, mimicking chronic obstructive pulmonary disease (COPD). This study establishes a new animal model for COPD research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine.

American journal of physiology. Cell physiology·2001
Same author

A single residue contributes to the difference between Kir4.1 and Kir1.1 channels in pH sensitivity, rectification and single channel conductance.

The Journal of physiology·2000
Same author

Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels.

American journal of physiology. Cell physiology·2000
Same author

Interaction of different oligomeric states of hexameric DNA-helicase RepA with single-stranded DNA studied by analytical ultracentrifugation.

FEBS letters·2000
Same author

Function of GATA transcription factors in preadipocyte-adipocyte transition.

Science (New York, N.Y.)·2000
Same author

DNA helicase RepA: cooperative ATPase activity and binding of nucleotides.

Biochemistry·2000

Area of Science:

  • Pulmonary Medicine
  • Microbiology
  • Pathology

Background:

  • Chronic obstructive pulmonary disease (COPD) pathogenesis is complex.
  • The role of bacterial infections in COPD development requires further investigation.

Purpose of the Study:

  • To investigate the role of bacterial infections in the pathogenesis of COPD.
  • To establish a reliable animal model for studying COPD.

Main Methods:

  • An animal model of COPD was developed by intranasal administration of Klebsiella pneumoniae or Streptococcus pneumoniae in rats.
  • Histomorphological changes, arterial blood gases (PaO2, PaCO2), and right ventricular systolic pressure (RVSP) were analyzed.

Main Results:

  • Intranasal bacterial instillation led to bronchiolar injury, inflammation, and emphysema.

Related Experiment Videos

  • Significant increases in RVSP were observed in both experimental groups.
  • Long-term exposure to Klebsiella pneumoniae resulted in decreased PaO2 and increased PaCO2.

    • Conclusions:

    • Repeated intranasal bacterial instillation effectively induces small airway inflammation and emphysema in rats.
    • The established animal model exhibits key features of COPD, including pulmonary hypertension and impaired gas exchange.
    • This model serves as a valuable tool for exploring COPD pathogenesis and therapeutic strategies.