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Cell surface bound and soluble adhesion molecules in CSF and blood in multiple sclerosis: correlation with

J Kraus1, B Engelhardt, N Chatzimanolis

  • 1Department of Neurology, Justus-Liebig University Giessen, Research Group for Multiple Sclerosis and Neuroimmunology, Am Steg 14, 35385, Giessen, Germany. joerg.r.kraus@neuro.med.uni-giessen.de

Journal of Neuroimmunology
|January 5, 2002
PubMed
Abstract

Insights

Decreased cell surface bound adhesion molecules (AM) in the blood of multiple sclerosis (MS) patients may indicate subclinical disease progression and central nervous system (CNS) involvement.

Area of Science:

  • Neuroimmunology
  • Biomarker Discovery

Background:

  • Soluble cell adhesion molecules (AM) in cerebrospinal fluid (CSF) and blood are studied for multiple sclerosis (MS) disease activity.
  • Previous research indicated cell surface bound AM on mononuclear cells (MNC) in CSF and blood may reflect clinical MS activity.

Purpose of the Study:

  • To correlate cell surface bound and soluble AM in CSF and blood with MRI markers of subclinical MS disease severity and activity.

Main Methods:

  • Flow cytometry analyzed cell surface bound AM on MNC from 77 MS patients (33 CSF).
  • Enzyme-linked immunosorbent assay (ELISA) measured soluble AM concentrations.
  • Gadolinium-enhanced MRI assessed subclinical disease severity and activity.

Main Results:

  • Cell surface bound AM in peripheral blood inversely correlated with subclinical disease severity and activity on MRI, and disease duration.
  • Soluble AM serum levels correlated with patient age, but not disease duration.

Conclusions:

  • Decreased expression of cell surface bound AM on peripheral blood MNC may be linked to subclinical MS progression.
  • This decrease might reflect activated MNC migration into the central nervous system (CNS).

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