Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental study on prefabricating iliac grafts using composite bone].

Q Ma1, T Mao, B Liu

  • 1College of Stomatology, Fourth Military Medical University, Xi'an Shanxi, P. R. China 710032. maqinsoh@pub.xaonline.com

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

[Study of the cytotoxity against human hepatocellular carcinoma cells induced by the MAGE-1 gene modified dendritic cells].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2001
Same author

Anodic cyclization reactions: reversing the polarity of ketene dithioacetal groups.

Organic letters·2001
Same author

Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration.

American journal of physiology. Heart and circulatory physiology·2001
Same author

Assessment of total energy expenditure in a Chinese population by a physical activity questionnaire: examination of validity.

International journal of food sciences and nutrition·2001
Same author

Downregulation of the ERK 1 and 2 mitogen activated protein kinases using antisense oligonucleotides inhibits proliferation of porcine vascular smooth muscle cells.

Atherosclerosis·2001

Coral and type I collagen effectively carry recombinant human bone morphogenetic protein-2 (rhBMP-2) to create shaped bone grafts. This technique shows great potential for reconstructive surgery.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Context:

  • Bone defects present significant reconstructive challenges.
  • Autografts are limited by donor site morbidity and availability.
  • Tissue-engineered solutions offer promising alternatives.

Purpose:

  • To assess the feasibility of fabricating a shaped autograft using coral and type I collagen as carriers for recombinant human bone morphogenetic protein-2 (rhBMP-2).
  • To evaluate the potential of this composite for microvascular free tissue transfer.

Summary:

  • A composite of rhBMP-2, coral, and type I collagen was shaped and implanted in a canine iliac defect with a titanium implant.
  • Histological and radiographic analysis at 3 and 4.5 months demonstrated bone formation and integration with the implant.

Related Experiment Videos

  • The new bone matured, indicating successful osteogenesis within the engineered graft.

    • Impact:

    • Coral and type I collagen serve as effective carriers for rhBMP-2 in fabricating vascularized, shaped osteomuscular autografts.
    • rhBMP-2 facilitated tissue-engineered bone flaps with significant potential for maxillofacial reconstruction.
    • This approach offers a novel dimension to reconstructive surgery by enabling custom-shaped bone grafts.