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[Clinical significance of sentinel lymph node biopsy in breast cancer]
1Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Objective:
To study the necessity, feasibility, accuracy and clinical value of sentinel lymph node(SLN) biopsy in the management of breast cancer.
Methods:
Technetium-99m labeled colloid particles were injected subcutaneously below the breast tumor before mastectomy. The sentinel lymph nodes identified by lymphoscintigraphy and gamma-counter were dissected out from the excised axillary tissue and separately examined manually for consistency and histologically.
Results:
In 30 cases studied, SLNs were identified in all but one, with a detection rate of 96.7%. Metastases were detected in SLNS in 8 cases. The other case showed positive axillary lymph nodes but SLN was negative. The sensitivity of SLN biopsy in this study was 88.9%, accuracy was 93.3%, false positive was 0, false negative was 11.1%.
Conclusion:
SLN biopsy, though still under investigation, may in the future substitute routine axillary lymph node dissection in the management of breast cancer.
