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[Clinicopathologic criteria for the diagnosis of extranodal anaplastic large-cell lymphoma: a preliminary study]
Objective:
To study and observe the clinicopathologic features of extranodal Ki-1 (CD30) positive anaplastic large-cell lymphoma (ALCL) in order to assess its diagnostic criteria.
Methods:
Lymph nodes of 12 patients with Ki-1 positive ALCL were examined histopathologically and immunohistochemically.
Results:
There were distinctive histopathological features of ALCL cells. Immunohistochemical staining revealed that all of the ALCL were Ki-1 positive (CD30 or Ber-H2). Of them, 5 cases were leucocyte common antigen (LCA) and epithelial membrane antigen (EMA) positive, 2 cases were LCA negative and EMA positive, 1 case was LCA positive and EMA negative, and the other 4 cases were both negative. Seven cases (58.3%) showed B cell markers, 2 cases (16.7%) showed T cell markers and remaining 3 cases had neither T nor B markers.
Conclusion:
Extranodal Ki-1 (CD30) positive ALCL has distinctive histopathologic and immunohistochemical features which help its differential diagnosis.
