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[127 cases of pulmonary fungal infection]
1Department of Respiratory Disease, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Objective:
To find out the clinical features, therapeutic outcome, prognosis and the major predisposing diseases of pulmonary fungal infection(PFI).
Method:
127 cases with PFI were retrospectively analyzed.
Results:
Various predisposing diseases were found in 95% of total cases, among them, COPD, systemic lupus erythromatus(SLE), leukemia and chronic renal disease were main predisposing diseases. Primary pulmonary fungal infection was rare. All the clinical manifestations of PFI were not specific, reontgenographic features showed mainly bronchitis type(61%). Monilia (Candida) was ranked the first pathogen (79.5%). The mortality of PIF was high. Chronic renal and hematological diseases might be the risk factors for mortality (RR, relative rate, 5.14).
Conclusions:
PFI is an important cause of the secondary infection in many diseases. The clinical features of PFI is non-specific and the morbidity is rising. Clinicians should pay more attention to it.
Insights
Pulmonary fungal infections (PFI) often occur in patients with underlying diseases like COPD or leukemia. Early recognition is crucial as PFI has non-specific symptoms and high mortality, especially in those with chronic renal or hematological conditions.
Area of Science:
- Pulmonology
- Infectious Diseases
- Mycology
Background:
- Pulmonary fungal infection (PFI) is a significant secondary infection in various underlying diseases.
- Predisposing conditions, including chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), leukemia, and chronic renal disease, are prevalent in PFI cases.
Purpose of the Study:
- To elucidate the clinical characteristics of pulmonary fungal infections.
- To evaluate the therapeutic outcomes and prognosis of PFI.
- To identify major predisposing diseases associated with PFI.
Main Methods:
- Retrospective analysis of 127 cases diagnosed with pulmonary fungal infection.
Main Results:
- 95% of patients had predisposing diseases, with COPD, SLE, leukemia, and chronic renal disease being most common.
- Clinical manifestations were non-specific; bronchitis-type findings on radiography were observed in 61% of cases.
- Monilia (Candida) was the predominant pathogen (79.5%). High mortality was noted, with chronic renal and hematological diseases identified as risk factors (RR 5.14).
Conclusions:
- Pulmonary fungal infection is a critical secondary infection, with increasing morbidity.
- Non-specific clinical features necessitate heightened clinical awareness.
- Prompt diagnosis and management are essential, particularly in immunocompromised or chronically ill patients.