[The relationship between maternal infection with human parvovirus B19 and fetal death and congenital malformation]
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Updated: Aug 9, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
1Department of Obstetrics and Gynecology, Central Hospital of Xi'an City, 710003 China.
Objective:
To study the relationship between matanal infection with human parvovirus B19 and fetal death and congenital malformation.
Method:
B19-DNA was detected by Polymerase Chain Reaction (PCR) in blood samples from 335 pregnant women. The pregnant outcomes were followed.
Results:
In 335 pregnant women, 67 cases were B19-DNA positive and 268 cases were B19-DNA regative. There were four fetal deaths and one anencephalus in B19-DNA positive group. There was no fetal deaths or congenital malformation in B19-DNA negative group. The difference is significant (P < 0.05).
Conclusions:
Maternal infection with human parvovirus B19 may contribute to fetal death and congenital malformation.
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