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The dual association between lymphoma and autoimmunity
M Ehrenfeld1, M Abu-Shakra, D Buskila
1Research Centre for Autoimmune Diseases, Sheba Medical Centre, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Blood Cells, Molecules & Diseases
|January 10, 2002
Summary
Autoimmune rheumatic diseases and lymphocytic cancers are linked, with each condition increasing the risk of the other. This bidirectional relationship is observed in conditions like rheumatoid arthritis and lupus.
Area of Science:
- Rheumatology
- Oncology
- Immunology
Background:
- A bidirectional association exists between autoimmune rheumatic diseases and lymphocytic malignancies.
- Lymphomas are more common in patients with autoimmune diseases, and rheumatic manifestations appear in patients with lymphocytic malignancies.
- Conditions such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and autoimmune thyroid disease show an increased incidence of malignant lymphocytic diseases.
Purpose of the Study:
- To explore the intricate relationship between autoimmune rheumatic conditions and lymphocytic cancers.
- To highlight the bidirectional nature of this association, where each condition can precede or influence the other.
Main Methods:
- Review of published literature and case descriptions.
- Analysis of the co-occurrence and temporal relationship between autoimmune rheumatic diseases and lymphocytic malignancies.
Main Results:
- An increased incidence of lymphocytic malignancies is noted in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and autoimmune thyroid disease.
- Autoimmune rheumatic manifestations have been described in patients with lymphocytic malignancies.
- In some instances, the diagnosis of lymphocytic malignancy precedes the onset of rheumatic disease by months or years.
Conclusions:
- The association between autoimmune rheumatic diseases and lymphocytic malignancies is significant and bidirectional.
- Clinicians should be aware of the potential for co-occurrence and the varied temporal presentation of these conditions.