Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern.

A M Booth¹, R D LeGallo, M H Stoler

¹Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|January 10, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A scenario-based risk assessment framework for tyre wear particles in European seas.

Journal of hazardous materials·2026

Same author

Rainfall triggers more deep-seated landslides than Cascadia earthquakes in the Oregon Coast Range, USA.

Science advances·2020

Same author

Combined effects of exposure to engineered silver nanoparticles and the water-soluble fraction of crude oil in the marine copepod Calanus finmarchicus.

Aquatic toxicology (Amsterdam, Netherlands)·2020

Same author

Phase IB study of the combination of docetaxel, gemcitabine, and bevacizumab in patients with advanced or recurrent soft tissue sarcoma: the Axtell regimen.

Annals of oncology : official journal of the European Society for Medical Oncology·2011

Same author

The immunohistochemical method.

Methods in molecular medicine·2011

Same author

IgA nephropathy in the triethnic population of New Mexico.

Clinical nephrology·2009

Same journal

Early-Onset Severe Liver Fibrosis in a Toddler with Erythropoietic Protoporphyria Associated with Rare Compound Heterozygous FECH Variants.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Same journal

Fetiform Teratoma With a Digitiform Projection and Complex Organoid Differentiation (Adrenal and Pancreatic).

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Same journal

Characterizing Fetal Hemorrhage in a Perinatal Autopsy Cohort.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Same journal

The Hepatic Histomorphology and Application of Ensemble Transfer Learning in Convolutional Neural Network Models in the Biopsies of Hepatic Langerhans Cell Histiocytosis.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Same journal

Drug Induced Liver Injury in Children: Practical Considerations for Pathologists.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Same journal

Childhood-Onset Desmin-Related Cardiomyopathy: Comprehensive Clinical, Histopathological, Immunohistochemical, Ultrastructural, and Molecular Characterization.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

See all related articles

This report details the seventh pediatric cardiac angiosarcoma case in a 23-month-old female. The rare tumor presented with metastases, highlighting unusual features and the limited understanding of pediatric cardiac angiosarcoma.

Area of Science:

Pediatric Oncology
Cardiovascular Pathology
Rare Tumor Research

Background:

Cardiac angiosarcoma is exceptionally rare in children, with only six prior cases documented.
Pediatric cardiac tumors often present with nonspecific symptoms, complicating early diagnosis.

Observation:

A 23-month-old female developed pericardial tamponade post-femur biopsy, revealing a large intracardiac mass.
Histopathology confirmed angiosarcoma with pleomorphic cells expressing endothelial markers (CD31, CD34, FVIII-RA).
Metastases were widespread, involving the brain, ovaries, and bone marrow.

Findings:

This case represents the seventh pediatric cardiac angiosarcoma, notable for its young patient age and left-sided cardiac location.
The tumor presented with extensive metastatic disease, unusual for pediatric cardiac angiosarcoma.

Related Experiment Videos

The patient succumbed to metastatic disease complications eight months after initial presentation.

Implications:

This case underscores the aggressive nature and metastatic potential of pediatric cardiac angiosarcoma.
Further research is needed to understand the unique biology and develop targeted therapies for this rare malignancy.
Highlights the importance of considering rare cardiac tumors in pediatric differential diagnoses, especially with metastatic presentations.