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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

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Related Experiment Video

Updated: Jun 23, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

microRNAs: tiny regulators with great potential.

V Ambros1

  • 1Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. vra@dartmouth.edu

Cell
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Small regulatory RNAs, known as microRNAs, are abundant in animal genomes. Their diversity and widespread presence suggest crucial roles in various genetic regulatory pathways.

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Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • Animal genomes encode numerous small genes.
  • These genes produce regulatory RNAs approximately 22 nucleotides in length.
  • These small RNAs are identified as microRNAs.

Purpose of the Study:

  • To investigate the characteristics of microRNAs.
  • To understand the potential roles of microRNAs in genetic regulation.

Main Methods:

  • Bioinformatic analysis of animal genomes.
  • Sequence analysis of small RNAs.
  • Comparative genomics to assess evolutionary distribution.

Main Results:

  • MicroRNAs are diverse in their nucleotide sequences.
  • MicroRNAs exhibit varied expression patterns across different tissues or conditions.
  • MicroRNAs are found to be evolutionarily widespread across animal species.

Conclusions:

  • The sequence diversity and broad evolutionary presence of microRNAs indicate significant biological functions.
  • MicroRNAs likely play a critical role in a wide array of genetic regulatory networks.
  • Further research into microRNA function is warranted to elucidate their impact on gene expression and cellular processes.