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Updated: Aug 19, 2026
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
DNA microarray analysis of gene expression markers of endometriosis
Kathleen M Eyster1, Amy L Boles, John D Brannian
1Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069-2390, USA. keyster@usd.edu
Objective:
To use DNA microarray technology to examine differential gene expression in uterine endometrium versus endometriosis implants.
Design:
Pilot study.
Setting:
Volunteers in an academic research environment.
Patient(S):
Premenopausal women scheduled for surgery for suspected endometriosis.
Intervention(S):
Surgical excision of endometriosis tissue and uterine endometrial biopsy.
Main Outcome Measure(S):
Gene expression.
Result(S):
The expression of eight genes from a total of 4,133 genes on the DNA microarray was increased in endometriosis implants compared with uterine endometrium. The eight genes were beta-actin, alpha-2 actin, vimentin, 40S ribosomal protein S23, Ig-lambda light chain, Ig germline H chain G-E-A region gamma-2 constant region gene, major histocompatibility complex class 1,C, and complement component 1 S subcomponent.
Conclusion(S):
The data demonstrate that the DNA microarray is an effective tool for the identification of differentially expressed genes between uterine and ectopic endometrium; further study of the genes identified herein will expand our understanding of the nature of endometriosis and assist in the eventual development of new treatments for endometriosis.
