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3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
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Angiogenic factors and bladder cancer.
1Department of Surgery, Cancer Hospital/Cancer Institute, Fu Dan University, Shanghai, 200032, P. R. China.
Frontiers in Bioscience : a Journal and Virtual Library
|January 10, 2002
Summary
Tumor growth relies on angiogenesis, the formation of new blood vessels. Angiogenic factors like VEGF and bFGF are key in bladder cancer, potentially aiding diagnosis and prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Angiogenesis is crucial for solid tumor growth and expansion.
- Tumor angiogenesis is regulated by the balance of angiogenic factors and inhibitors.
- Imbalances in these factors are implicated in various cancers.
Purpose of the Study:
- To investigate the role of angiogenic factors and inhibitors in bladder cancer.
- To identify key pro-angiogenic mediators in bladder cancer physiology.
- To explore the diagnostic and prognostic potential of angiogenic factors in bladder cancer.
Main Methods:
- Review of existing literature on tumor angiogenesis.
- Analysis of the roles of specific angiogenic factors (VEGF, bFGF) in bladder cancer.
- Discussion of the clinical relevance of angiogenic mediators.
Main Results:
- Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF) are identified as significant pro-angiogenic mediators in bladder cancer.
- An increase in angiogenic factors and a decrease in inhibitors can trigger tumor angiogenesis.
- The study highlights the physiological relevance of VEGF and bFGF in bladder cancer.
Conclusions:
- Angiogenic factors and inhibitors are critically involved in bladder cancer development.
- VEGF and bFGF are particularly important in the context of bladder cancer angiogenesis.
- These angiogenic factors and inhibitors show promise for improving bladder cancer diagnosis and prognosis.
