Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Entry into host cells by Legionella.

Mustapha M Samrakandi1, Dennis A Ridenour, Ling Yan

  • 1Dept. of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, 203 VBS, Fair and East Campus Loop, Lincoln, NE 68583, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen Vacancy-Mediated Bi─O Unsaturation Coordination in BiOCl for Efficient Photocatalytic Water Purification.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours.

Frontiers in pediatrics·2026
Same author

Optimization of Deep Eutectic Solvent Extraction Process and Study on the Anti-Alcoholic Fatty Liver Disease Activity and Mechanism of Flavonoids From Lophatherum gracile Brongn.

Chemical biology & drug design·2026
Same author

Emotional labor and emotional exhaustion among physical education teachers: The moderating role of social support.

Work (Reading, Mass.)·2026
Same author

MMTC-Net: Multimodal Temporal Cervical Network for HSIL+ Recognition in Precancer Screening.

Journal of imaging informatics in medicine·2026
Same author

Metabolic complementarity in LAB-yeast co-fermentation associates with enhanced ester aroma in cream cheese.

Food research international (Ottawa, Ont.)·2026
Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Lurie's tubercle-count method to test TB vaccine efficacy in rabbits.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying rotavirus gastroenteritis.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017
See all related articles

Legionella bacteria cause Legionnaires' disease by entering host cells. Understanding these entry mechanisms is crucial for preventing infections and developing better treatments for this serious respiratory illness.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Cell Biology

Background:

  • Legionnaires' disease is a severe respiratory infection caused by the intracellular bacterium Legionella.
  • Predicting and preventing Legionella outbreaks remains a significant challenge.
  • Legionella's ability to enter and replicate within host cells is key to its pathogenesis and environmental survival.

Purpose of the Study:

  • To explore the critical mechanisms by which Legionella invades host cells.
  • To understand the early events in Legionella pathogenesis, focusing on host cell entry.
  • To identify potential targets for preventing Legionella infections.

Main Methods:

  • Review of existing literature on Legionella-host cell interactions.
  • Analysis of known bacterial invasion strategies.

Related Experiment Videos

  • Discussion of cellular processes involved in Legionella entry.

    • Main Results:

    • Legionella entry into host cells involves multiple steps: host cell recognition, adherence, signal transduction, and internalization.
    • Successful entry and initial survival are essential for intracellular replication and disease progression.
    • The precise importance of each entry step in overall pathogenesis is not fully elucidated.

    Conclusions:

    • Host cell entry is a critical determinant of Legionella survival and replication.
    • Further research into Legionella entry mechanisms may reveal novel strategies for disease prevention.
    • Understanding these processes is vital for mitigating the public health and economic impact of Legionnaires' disease.