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Related Concept Videos

Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

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Related Experiment Video

Updated: Jul 20, 2026

Measuring the Strength of Mice
06:17

Measuring the Strength of Mice

Published on: June 2, 2013

A case of weak muscles.

N Sofat1, M Pitcher, A Price

  • 1Department of Rheumatology, Northwick Park and St Mark's Hospitals, Watford Road, Harrow HA1 3UJ, UK.

Annals of the Rheumatic Diseases
|January 10, 2002
PubMed
Summary

Inflammatory myositis rarely affects the gut. This case study shows that treating eosinophilic gastroenteritis and polymyositis together with immunosuppression improved both gastrointestinal and muscle symptoms.

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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

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Related Experiment Videos

Last Updated: Jul 20, 2026

Measuring the Strength of Mice
06:17

Measuring the Strength of Mice

Published on: June 2, 2013

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Immunology

Background:

  • Gut involvement in inflammatory myositis is uncommon but associated with severe outcomes.
  • Eosinophilic gastroenteritis and polymyositis are distinct conditions with potential overlap.

Observation:

  • A rare case presented with concurrent eosinophilic gastroenteritis and polymyositis.
  • The study examined the interplay between visceral and striated muscle inflammation.

Findings:

  • Immunosuppressive therapy led to simultaneous improvement in both gastrointestinal and skeletal muscle symptoms.
  • This suggests a shared pathophysiological pathway may link these conditions.

Implications:

  • Early recognition and combined treatment approaches may be beneficial for patients with overlapping gastrointestinal and myositis symptoms.
  • Further research into the common mechanisms underlying eosinophilic gastroenteritis and inflammatory myositis is warranted.