Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two-locus sampling distributions and their application.

R R Hudson1

  • 1Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA. rr-hudson@uchicago.edu

Genetics
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.

American journal of human genetics·2005
Same author

Type I error and the power of the s-test: old lessons from a new, analytically justified statistical test for phylogenies.

Systematic biology·2002
Same author

Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels.

American journal of human genetics·2001
Same author

Coalescent simulations and statistical tests of neutrality.

Molecular biology and evolution·2001
Same author

LIAN 3.0: detecting linkage disequilibrium in multilocus data. Linkage Analysis.

Bioinformatics (Oxford, England)·2000
Same author

A new statistic for detecting genetic differentiation.

Genetics·2000
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
Same journal

Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

Genetics·2026
Same journal

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Genetics·2026
Same journal

Neural and Genetic Mechanisms Regulating Copulation Latency in Male Drosophila melanogaster.

Genetics·2026
See all related articles

This study extends methods for estimating genetic linkage disequilibrium probabilities under neutral models. Analysis of human X chromosome regions reveals a recombination rate significantly lower than predicted by neutral theory.

Area of Science:

  • Population genetics
  • Statistical genetics

Background:

  • Estimating genetic variation and recombination rates is crucial for understanding evolutionary processes.
  • Existing methods for two-locus sample probabilities under neutral models have limitations.

Purpose of the Study:

  • To extend methods for estimating two-locus sample probabilities under neutral models.
  • To develop and evaluate estimators for the recombination parameter.
  • To test for unusual levels of linkage disequilibrium.

Main Methods:

  • Extended estimation of two-locus sample probabilities with specified ancestral/derived allele status.
  • Developed methods for two-locus diploid samples.
  • Derived properties of maximum-likelihood and composite-likelihood estimators for the recombination parameter.

Related Experiment Videos

  • Analyzed linkage disequilibrium in human Xq28 and Xq25 regions.

    • Main Results:

    • Provided methods for estimating probabilities in specified allele states and for diploid samples.
    • Developed and evaluated composite-likelihood estimators for the recombination parameter, outperforming ad hoc methods.
    • Observed a recombination parameter approximately five times smaller than expected under neutral equilibrium in human X chromosome regions.

    Conclusions:

    • The extended methods provide robust tools for analyzing genetic linkage and recombination.
    • The findings suggest a lower recombination rate in specific human X chromosome regions than predicted by neutral models, potentially indicating selection or other evolutionary forces.