Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-sensitivity CCD-based X-ray detector.

Walter C Phillips1, Alexander Stewart, Martin Stanton

  • 1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA. phillips@brandeis.edu

Journal of Synchrotron Radiation
|January 10, 2002
PubMed
Summary

This study presents a novel X-ray detector with high sensitivity and spatial resolution, capable of single photon detection and fast readout for advanced imaging applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pangenomic analysis of the bacterial cellulose-producing genera Komagataeibacter and Novacetimonas.

International journal of biological macromolecules·2025
Same author

Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes.

Cell reports·2024
Same author

Lunar-linked biological rhythms in the immune system of freshwater three-spined stickleback.

Discovery immunology·2024
Same author

Diversification of immunoglobulin genes by gene conversion in the domestic chicken (<i>Gallus gallus</i> domesticus).

Discovery immunology·2024
Same author

Thioredoxin is a metabolic rheostat controlling regulatory B cells.

Nature immunology·2024
Same author

B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma.

Nature communications·2023

Area of Science:

  • Medical Imaging
  • Photon Detection
  • Detector Technology

Background:

  • Traditional X-ray detectors often compromise between sensitivity, spatial resolution, and dynamic range.
  • There is a need for detectors that can accurately image low-intensity X-ray signals with high detail.

Purpose of the Study:

  • To develop and characterize a novel X-ray detector with high sensitivity and spatial resolution.
  • To evaluate the detector's performance in discriminating single X-ray photons and its dynamic range.
  • To assess the detector's suitability for time-resolved experiments.

Main Methods:

  • Utilized a Gadolinium Oxysulfide (GdO2S2) phosphor screen for X-ray to optical conversion.
  • Employed a fiber optic faceplate for lossless optical coupling to a large-area CCD sensor (4.9 x 8.6 cm, 12 µm pixels).

Related Experiment Videos

  • Characterized detector performance using visible-light, X-ray imaging, and time-resolved muscle diffraction.

    • Main Results:

    • Achieved single X-ray photon discrimination with a signal of 100 e- per 12 keV photon.
    • Demonstrated a wide dynamic range of approximately 10000:1.
    • Obtained a spatial resolution of 50 µm and detective quantum efficiency >0.6 at 1 X-ray photon per pixel.
    • Achieved full image readout in under 4 seconds with computer-controlled flexibility.

    Conclusions:

    • The developed X-ray detector offers a unique combination of high sensitivity, spatial resolution, and wide dynamic range.
    • Its capability for single photon counting and fast readout makes it suitable for demanding imaging tasks.
    • The detector's performance is validated for various applications, including time-resolved studies.