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[Effect of lost bite force on the expression of bFGF in rat molar periodontal ligament]
1Department of Prosthodontics, College of Stomatology, West China University of Medical Sciences, Chengdu 610041, China.
Objective:
To observe the dynamic change of the expression of basic fibroblast growth factor (bFGF) in rat molar periodontal ligament(PDL), combined with other experiments to probe into the relation of the expression between bFGF and type I collagen mRNA.
Methods:
Animal model was established by extracting the left maxillary molars. Immunohistochemistry was applied.
Results:
The expression of bFGF obviously increased from the first day to the second week (P < 0.05), Came back to that of normal bite force group at the third week. There were strong negative relative relationship between the expression of bFGF and that of type I collagen mRNA.
Conclusion:
The expression of bFGF increased under lost bite force in rat molar PDL. The effect of bite force on the expression of PDL type I collagen mRNA is closely related to the expression of bFGF.
