Related Experiment Videos
[Morphometrical study on the development of the trisomy-18 with cleft palate and euploid mice]
Z Cai1, H von Domarus, E Engel
1Department of Oral and Maxillofacial Surgery, School of Stomatology, Bejing Medical University, Beijing 100081, China.
Objective:
To quantitatively compare the whole body, the lateral maxillofacial profile in Ts18 foetuses with cleft palate (Ts + CP) and euploid foetuses in order to answer the question whether this animal model is associated with maldevelopment or hypoplasia of the craniomaxillofacial region.
Methods:
Sixty female Hanmice and 11 male mice with the Rb(2.18) 6Rma and Rb(1.18) 10Rma chromosomes were used to generate 569 living foetuses. Of these, 52 pairs Ts + CP and euploid foetuses were selected according to about equal body weight, and used in gross morphometric study.
Results:
Ts + 18 foetuses had greater body flexion, a significant maxillary and mandibular retrusion, also mandible in Ts + CP foetuses were smaller than in euploids without cleft.
Conclusions:
This animal model of congenital cleft palate developed hypoplasia of the maxilla and mandible.