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Infections caused by Flavimonas oryzihabitans
1Department of Hematology and Oncology, Second People's Hospital of Changzhou, Changzhou 213003, China.
Chinese Medical Journal
|January 10, 2002
Summary
Flavimonas oryzihabitans infections are rare and often linked to underlying diseases or foreign materials. These infections are associated with significantly weakened immune function, particularly T lymphocyte and NK cell levels.
Area of Science:
- Medical Microbiology
- Immunology
Background:
- Flavimonas oryzihabitans (F. oryzihabitans) is a rare bacterial pathogen.
- Understanding its clinical impact and host immune response is crucial for effective management.
Purpose of the Study:
- To retrospectively analyze the clinical characteristics of F. oryzihabitans infections.
- To evaluate the cell immune function in patients with F. oryzihabitans infections.
Main Methods:
- Identified 11 cases of F. oryzihabitans from hospital cultures (1994-1998).
- Collected clinical data, including demographics, underlying diseases, and manifestations.
- Determined antimicrobial susceptibility and assessed T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8 ratio) and NK cells (CD16+56) via flow cytometry.
Main Results:
- Most patients (mean age 47.64 years) had severe underlying diseases and developed infection during hospitalization.
- Primary bacteremia was the most common manifestation (72.7%).
- Isolates were susceptible to amikacin, gentamicin, and ciprofloxacin, but resistant to penicillin-based antibiotics. Immune cell counts (CD3, CD4, CD4/CD8, CD16+56) were significantly lower than normal (P < 0.01).
Conclusions:
- F. oryzihabitans infections are infrequent and associated with underlying conditions and foreign materials.
- Abnormal immune function is a significant contributing factor to F. oryzihabitans infections.
- Prompt antibiotic treatment led to recovery in all studied patients.