[The induction of transforming growth factor-beta 1 in reparative process of mouse experimental alveolar bone defect]
1Department of Oral Medicine, College of Stomatology, Xi'an Medical University, Xi'an 710004, China.
Objective:
To study the induction of transforming growth factor-beta 1(TGF-beta 1) in reparative process of mouse experimental alveolar bone defect.
Methods:
Alveolar bone defect were made in 20 mice at 1/1 region. In twelve mice (experimental group), the defect was filled with gelatin sponge infiltrated by TGF-beta 1 solution; in eight mice (control group), the defect was filled with gelatin sponge. The peripheral tissue coating alveolar bone defect was harvested for histopathologic study after 1 week, 2 weeks and 1 month, 3 months.
Results:
The main histopathologic changes were: 1. experimental group: inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis, osteoid tissue and small amount neoformative bone tissue appearance (2 W); fibrous tissue decrease, neoformative bone tissue enlarging and maturity(1-3 M). 2. Control group; inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis (2W); osteoblast appearance around bone defect (1M); small amount neoformative bone tissue around bone defect.
Conclusion:
TGF-beta 1 can induce alveolar bone regeneration.
