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Articular lesions in experimental Erysipelothrix insidiosa infection in rats
Abstract:
Articular lesions were studied in the extremities and vertebral column in murine erysipelas infection. Pathologic alterations found in those different joint systems were essentially the same in character. In the early stage of infection, phlegmon-like inflammation was observed in the periarticular loose connective tissue. Abundant fine Gram-positive bacilli were free in inflamed edematous tissue. Then, active serofibrinous exudation and emigration of leukocytes occurred in the synovial membrane, articular cartilage, annulus fibrosus, and nucleus pulposus with the development of the disease. These exudative changes disappeared gradually. Instead of them, proliferation of synovial cells accompanied by dense infiltration with lymphocytes and plasma cells became conspicuous. At the same time, chondro- and osteoclastic activity occurred in the joints of the extremities or regions adjacent to the intervertebral disk. Capsular and subchondral pannus often resulted from an excessive proliferation of granulation tissue. In the late stage, they synovial membrane and granulation tissue underwent fibrosis, adhesion and ossification. Finally, these changes resulted in fibrous or bony ankylosis and deformation. Gram-positive bacilli were hardly detected in histological preparations derived from animals in the chronic stage when proliferative change was predominant in the articular lesions.
Insights
Murine erysipelas infection causes significant articular lesions in extremities and the vertebral column. The study details the progression from inflammation to ankylosis, offering insights into joint disease pathogenesis.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Musculoskeletal System Research
Background:
- Erysipelas infection in mice can affect joint structures.
- Understanding articular pathology in erysipelas is crucial for disease management.
Purpose of the Study:
- To investigate the pathological alterations in articular tissues during murine erysipelas.
- To characterize the progression of joint lesions from early inflammation to chronic changes.
Main Methods:
- Histopathological examination of joints (extremities and vertebral column) in mice with erysipelas.
- Observation of inflammatory, exudative, proliferative, and degenerative changes.
- Detection of Gram-positive bacilli in affected tissues.
Main Results:
- Early stage: periarticular inflammation with Gram-positive bacilli.
- Disease development: serofibrinous exudation and leukocyte emigration in joint tissues.
- Late stage: synovial cell proliferation, chondro- and osteoclastic activity, pannus formation, fibrosis, ossification, leading to ankylosis and deformation.
- Gram-positive bacilli were rarely detected in chronic stages.
Conclusions:
- Murine erysipelas induces progressive articular lesions characterized by inflammation, exudation, proliferation, and ossification.
- These changes can culminate in joint deformation and ankylosis.
- The study elucidates the pathogenesis of erysipelas-induced arthritis in a murine model.