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Preputial separation and glans penis changes in normal growing Crj: CD (SD) IGS rats
1Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita1, Japan. yamasaki-kanji@hita.cerij.or.jp
Reproductive Toxicology (Elmsford, N.Y.)
|January 10, 2002
Summary
Preputial separation in Sprague Dawley (SD) rats is linked to changes in glans penis morphology. Complete separation coincides with a flattened glans surface, observed by postnatal day 44.
Area of Science:
- Developmental Biology
- Comparative Anatomy
- Rodent Models
Background:
- Understanding male reproductive development is crucial.
- Preputial separation is a key maturational event in rodents.
- Morphological changes in the glans penis accompany this process.
Purpose of the Study:
- To document the timeline of preputial separation.
- To characterize age-related changes in glans penis morphology.
- To correlate these events in Sprague Dawley (SD) rats.
Main Methods:
- Longitudinal observation of SD rats from birth to 53 days.
- Detailed examination of glans penis surface morphology.
- Recording the precise day of complete preputial separation.
Main Results:
- Glans penis morphology progresses from a protruding os penis to a W shape, then to a flattened surface.
- The W shape emerged between postnatal days 30-35.
- A flattened surface was observed from postnatal day 39, with full development by day 44.
- Complete preputial separation consistently occurred on the same day the flattened glans surface appeared.
Conclusions:
- Preputial separation in SD rats is a well-defined event.
- Glans penis morphology undergoes predictable changes during development.
- The appearance of a flattened glans surface is a reliable indicator of complete preputial separation.