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BIA-MS-MS: biomolecular interaction analysis for functional proteomics
T Natsume1, H Nakayama, T Isobe
1National Institute of Advanced Science and Technology, Biological Information Research Center (JBIRC), Tokyo, Japan. natsume@jbirc.aist.go.jp
Trends in Biotechnology
|January 10, 2002
Abstract:
One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA-MS, for protein interaction analysis. BIA-MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectrometry for the subsequent identification of interacting molecules.