Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network in pediatric rheumatology: the example of pediatric rheumatology international trials organisation.

Georgian medical news·2008
Same author

Aberrant internal carotid artery in the middle ear: two case reports.

B-ENT·2008
Same author

Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2008
Same author

Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intra-articular glucocorticoids.

Clinical and experimental rheumatology·2007
Same author

A longitudinal analysis of physical functional disability over the course of juvenile idiopathic arthritis.

Annals of the rheumatic diseases·2007
Same author

Measuring the psychosocial consequences of hearing loss in a working adult population: focus on validity and reliability of the Italian translation of the hearing handicap inventory.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2007

Related Experiment Video

Updated: Jul 10, 2026

Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Hearing in the elderly: a population study.

A Martini1, M Mazzoli, M Rosignoli

  • 1Servizio di Audiologia, Clinica ORL dell' Università di Ferrara, Italy.

Audiology : Official Organ of the International Society of Audiology
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Speech audiometry effectively identifies hearing difficulties in older adults, correlating with self-assessed disability. This method is valuable for assessing age-related hearing decline beyond simple detection thresholds.

More Related Videos

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners
07:52

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

Published on: March 13, 2026

Related Experiment Videos

Last Updated: Jul 10, 2026

Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners
07:52

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

Published on: March 13, 2026

Area of Science:

  • Gerontology
  • Audiology
  • Epidemiology

Background:

  • Age-related hearing loss is a significant issue impacting the elderly's quality of life.
  • Understanding the relationship between objective hearing measures and self-perceived disability is crucial for effective interventions.

Purpose of the Study:

  • To compare speech audiometry with self-assessed hearing disability in older adults.
  • To analyze factors influencing quality of life in the elderly, with a focus on auditory function.
  • To evaluate the utility of speech audiometry in assessing age-related hearing deficits.

Main Methods:

  • An epidemiological study was conducted on 2700 independently living individuals aged 65+ in the Veneto region, Italy.
  • Participants underwent home-based assessments including speech audiometry, Sanders' Speech Disability test, Mini Mental State Examination, and other health evaluations.
  • Analysis focused on auditory performance, self-reported disability, and error patterns in speech audiometry.

Main Results:

  • Auditory function significantly deteriorates in individuals over 75 years of age.
  • Speech audiometry results showed a strong correlation with self-reported auditory disability (Sanders' test).
  • Age-related hearing deficits encompass more than increased detection thresholds, including sound distortion and speech comprehension issues.

Conclusions:

  • Speech audiometry is a reliable indicator of actual hearing difficulties experienced by the elderly.
  • It may be preferable to pure-tone audiometry for capturing the multifaceted nature of age-related hearing loss.
  • Findings support the use of speech audiometry for a comprehensive assessment of hearing in older populations.