Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Moraxella catarrhalis: from emerging to established pathogen.

Cees M Verduin1, Cees Hol, André Fleer

  • 1Department of Medical Microbiology & Infectious Diseases, Erasmus University Medical Center Rotterdam EMCR, 3015 GD Rotterdam, The Netherlands. verduin@bacl.azr.nl

Clinical Microbiology Reviews
|January 10, 2002
PubMed
Summary

Moraxella catarrhalis has become a major human pathogen, causing respiratory and ocular infections. Advances in diagnostics and molecular tools track its spread and increasing antibiotic resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Global mapping of sexually transmitted Chlamydia trachomatis disease: a systematic review and meta-analysis.

BMC infectious diseases·2026
Same author

Being friendly to the skin microbiome: Experimental assessment.

Frontiers in microbiomes·2026
Same author

Point of care antimicrobial susceptibility testing.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2026
Same author

Insights into antibiotic resistance and prevalence of <i>Stenotrophomonas maltophilia</i> isolated from clinical samples in Iran: A systematic review.

New microbes and new infections·2025
Same author

Global mapping of sexually transmitted Chlamydia trachomatis disease: a systematic review and meta-analysis.

BMC infectious diseases·2025
Same author

Next generation sequencing as a panacea for antibiotic susceptibility testing: yea or nay?

Frontiers in public health·2025

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacterial Pathogenesis

Background:

  • Moraxella catarrhalis, formerly Branhamella catarrhalis, has emerged as a significant human pathogen over the last two decades.
  • Its role in various respiratory and ocular infections in both children and adults is well-documented.

Purpose of the Study:

  • To review the current knowledge on Moraxella catarrhalis, an organism that has evolved from an emerging to a well-established human pathogen.
  • To highlight advancements in diagnostic techniques, epidemiological tools, and understanding of virulence factors.

Main Methods:

  • Review of microbiological and molecular diagnostic techniques.
  • Analysis of epidemiological studies on strain distribution and carriage dynamics.
  • Examination of research on virulence factors, animal models, and molecular manipulation of M. catarrhalis genes.

Related Experiment Videos

Main Results:

  • Improved diagnostic and molecular tools have enhanced the identification and characterization of M. catarrhalis.
  • Epidemiological studies reveal widespread distribution and increasing prevalence of beta-lactamase-positive isolates (over 90%).
  • Research has identified putative virulence factors, but their direct role in pathogenesis is established in few cases; advancements in molecular manipulation offer insights into host response and vaccine candidates.

Conclusions:

  • Moraxella catarrhalis is a well-established human pathogen with increasing antibiotic resistance.
  • Continued research using advanced molecular techniques and suitable animal models is crucial for understanding its pathogenesis and developing effective interventions, including vaccines.