Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Micro-RNAs: small is plentiful.

Helge Grosshans1, Frank J Slack

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.

The Journal of Cell Biology
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cleavage of MEP-1 by DPF-3 reveals novel substrate specificity and its impact on reproductive fitness.

EMBO reports·2026
Same author

A microRNA atlas of the human prefrontal cortex across the adult lifespan.

bioRxiv : the preprint server for biology·2026
Same author

Large transgene arrays cause aberrant transcription and synthetic molting defects with <i>myrf-1</i> mutation.

bioRxiv : the preprint server for biology·2026
Same author

Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation.

Cell reports·2026
Same author

Advances in peptide nucleic acid for targeting RNA and genomic DNA.

Cell reports. Physical science·2026
Same author

MicroRNA spatial profiling for assessing drug efficacy in <i>BRCA1</i> -related triple-negative breast tumors.

bioRxiv : the preprint server for biology·2026
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

Two small RNAs regulate gene expression timing in C. elegans development. These micro-RNAs (miRNAs) are conserved across species, indicating broad roles in gene regulation.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Small temporally regulated RNAs (stRNAs) control gene expression timing during development.
  • Regulation occurs post-transcriptionally, distinct from RNA interference (RNAi).
  • The let-7 stRNA and its target lin-41 are conserved in humans.

Purpose of the Study:

  • To investigate the role of stRNAs in C. elegans development.
  • To explore the conservation and potential widespread function of stRNA-mediated gene regulation.
  • To highlight the significance of micro-RNAs (miRNAs) in metazoan gene regulation.

Main Methods:

  • Analysis of gene expression timing during C. elegans development.
  • Comparative analysis of RNA sequences and gene targets.

Related Experiment Videos

  • Literature review of conserved regulatory elements.

    • Main Results:

    • Two stRNAs, including let-7, were identified as key regulators of developmental timing.
    • The let-7 RNA and its target gene lin-41 show high conservation across species, including humans.
    • Evidence suggests a vast repertoire of miRNAs in metazoans, beyond the initially identified stRNAs.

    Conclusions:

    • stRNAs, particularly miRNAs, are crucial for regulating gene expression during development.
    • The conservation of let-7 and lin-41 points to ancient and widespread mechanisms of gene regulation.
    • miRNAs represent a significantly underestimated class of regulatory molecules with broad implications in biology.