Related Experiment Video
Updated: Aug 5, 2026

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
Published on: April 9, 2019
[Study on the intestinal microbial colonization resistance in patients with chronic severe hepatitis]
1Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, University of Zhejiang, Hangzhou 310003, China.
Objective:
To investigate the changes of microbial colonization resistance of the bowel in patients with chronic severe hepatitis.
Methods:
The fecal flora bifidobacteria, enterobacteriaceae, enterococci, and yeasts of subjects (chronic severe hepatitis, chronic hepatitis, and healthy volunteers) were quantitatively and qualitatively analyzed by Mitsuoka's methods. While the ratio of bifidobacterium to enterobacteriaceae ( B/E ratio ) was calculated.
Results:
The number of bifidobacteria and the B/E ratio in chronic severe hepatitis group was significantly deceased compared with that of the control group (P<0.001). The number of enterobacteriaceae and yeasts was significantly increased compared with that of control group (P<0.001 and P<0.01, respectively).
Conclusions:
The results suggest that the intestinal microbial colonization resistance in patients with chronic severe hepatitis is seriously impaired.
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Dysbiosis of the Gut Microbiota
Microbiota Modulation by Antibiotics

