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Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?
1Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3340 Smith Walk, Philadelphia, PA 19104, USA.
Developmental Cell
|January 10, 2002
Abstract:
Matrix metalloproteinases are enzymes that regulate tissue behavior by interactions with extracellular matrix proteins. RECK, a membrane-anchored inhibitor of MMPs was recently characterized for its role in development, tissue homeostasis, and for tumor angiogenesis.