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Updated: Jul 10, 2026
09:37
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Model organisms as a guide to mammalian aging.
Heidi A Tissenbaum1, Leonard Guarente
1Program in Gene Function and Expression, University of Massachusetts Medical School, New Research Building Suite 604, 364 Plantation Street, Worcester, MA 01605, USA. heidi.tissenbaum@umassmed.edu
Developmental Cell
|January 10, 2002
Summary
Aging regulation is conserved across species, influenced by nutrient availability and specific genes. Studies in yeast and roundworms suggest implications for mammalian aging processes.
Area of Science:
- Gerontology
- Molecular Biology
- Genetics
Background:
- Aging research has identified conserved regulatory pathways in model organisms.
- Nutrient availability and specific genes play crucial roles in modulating the aging process.
Purpose of the Study:
- To review conserved aging regulation mechanisms.
- To focus on findings in Caenorhabditis elegans and Saccharomyces cerevisiae.
- To highlight potential implications for mammalian aging.
Main Methods:
- Review of recent studies on aging in model systems.
- Comparative analysis of findings in yeast and roundworms.
Main Results:
- Conserved regulation of aging exists in response to nutrient levels.
- Specific genes are identified as mediators of this regulation.
- General features of aging regulation are consistent across studied models.
Conclusions:
- Aging processes share fundamental regulatory mechanisms.
- Understanding yeast and worm aging may inform mammalian aging research.
- Nutrient sensing pathways are key targets for aging interventions.
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