Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carbon monoxide-dependent signaling.

Danielle Morse1, Jigme Sethi, Augustine M K Choi

  • 1Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Critical Care Medicine
|January 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome.

Nature communications·2026
Same author

Relevant insights from personalized inhaled carbon monoxide dosing in a safety study in pneumonia and ARDS.

Respiratory research·2026
Same author

High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells.

American journal of physiology. Lung cellular and molecular physiology·2025
Same author

Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells.

The Journal of biological chemistry·2025
Same author

Effect of Single-Prong Cannula Design With High Velocity Therapy: Comparable Efficacy at Lower Gas Flow Rates.

Critical care explorations·2025
Same author

Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα- and CD24-Siglec10-Mediated Phagocytosis.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Carbon monoxide (CO) is emerging as a key signaling molecule in biological systems, similar to nitric oxide. CO activates soluble guanylyl cyclase and also exhibits novel, independent cytoprotective effects.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Nitric oxide (NO) is a well-established biological second messenger.
  • Carbon monoxide (CO), another diatomic gas, is increasingly recognized for its signaling roles.
  • CO shares some functions with NO, particularly in the vascular and nervous systems.

Purpose of the Study:

  • To explore the signaling mechanisms of carbon monoxide (CO) in biological systems.
  • To compare and contrast the actions of CO with those of nitric oxide (NO).
  • To investigate novel pathways and effects mediated by CO.

Main Methods:

  • Review of existing literature on CO and NO signaling.
  • Analysis of studies investigating CO's interaction with soluble guanylyl cyclase (sGC).

Related Experiment Videos

  • Examination of research on CO's effects independent of sGC, including cytoprotective roles.

    • Main Results:

    • CO activates soluble guanylyl cyclase, contributing to vasodilation and neurotransmission.
    • CO demonstrates signaling functions distinct from sGC activation.
    • CO exhibits cytoprotective effects against conditions like septic shock and lung injury in animal models.
    • The mitogen-activated protein kinase (MAPK) pathway is implicated in CO's cytoprotective actions.

    Conclusions:

    • Carbon monoxide (CO) is a versatile signaling molecule with diverse biological functions.
    • CO's actions involve both sGC-dependent and sGC-independent pathways.
    • Further research is ongoing to fully elucidate the complex cell signaling mechanisms of CO.